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Functional Cardiovascular Engineering Laboratory

The central theme of our research studies is to apply engineering techniques and methods to the solution of problems in the physiology of systemic cardiovascular and microvascular function in health and disease.

Our research applies a multiscale approach, where the initial stage is set by molecular biochemical interactions that produce cellular effects, which generate tissue changes. Their balance defines systemic regulation and new homeostatic set points. Fundamentally, our work is gas-driven living cellular behavior reprogramming, and our goal is to discover and analyze the underlying fundamental regulatory processes. The potential for translation of our research is highly significant, since most of the experimental studies are performed in whole mammalian organisms, preserving all the metabolic and regulatory mechanisms existing in physiological and pathophysiological conditions.

The nature of my research requires the translation of biological signals into quantitative measurement. I have a strong interest in applying my engineering skills to this endeavor, as well as developing new measuring techniques for exploring transport phenomena in the tissues, and quantifying tissue function at the cellular and microvascular level. My background is primarily in mechanical and electronic engineering, and I now have the needed biochemical expertise for attaining this goal. In this context, I plan to continue my work on the measurement of oxygen tension in the living tissue, combining optical and signal processing methods. This would be my starting point for analyzing gas function and metabolism. This work will merge into the analysis of the involvement of other gases, particularly nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S), ultimately leading to translational applications.

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